Hyaluronic acid and Niacinamide

Hyaluronic acid and Niacinamide are a great pair as both are water-based treatments. When used together, always apply hyaluronic acid first, followed by Niacinamide. By following this, you would be able to attract plenty of hydration first. After that, apply Niacinamide to help regulate the sebum production and help with the minimization of pores. Lastly, you can seal all the active ingredients by using a moisturizer. These ingredients are suitable for all skin types, and there are meager chances that your skin will be irritated by applying these ingredients together. Still, you can discontinue using one of the active ingredients and see which one triggered the skin in case of any discomfort or irritation. If not together, you can use both the active ingredients separately, like you can use the hyaluronic acid in your daytime skincare routine to feel hydrated enough throughout the day. Use Niacinamide in the night skincare routine to repair properties like help prevent the signs of aging, fine lines, wrinkles, dark spots, and enlarged pores.

If you suffer from dehydrated skin with an oily T zone, you can apply Niacinamide just on your nose, chin, and forehead. For the rest of the face, you can use hyaluronic acid to keep your skin well hydrated. When weighing up hyaluronic acid vs. Niacinamide, it’s a bit like comparing apples to oranges. These two ingredients are heavy-hitters in the skincare world, but they don’t work against each other. Instead, they can partner together to help you achieve more healthy, radiant, and youthful skin if you correctly sequence them into your routine. If you’re layering products, start with hyaluronic acid to a freshly cleansed and slightly damp face. Let your skin deeply absorb that serum or gel to ensure it locks in the moisture and works its hydrating and plumping powers on your epidermis. Follow up with Niacinamide toward the end of your routine. But you don’t have to use both at once. There’s always the option to use one product in the morning and the other at night. Try hyaluronic acid at the start of the day to help your skin stay hydrated. Then, apply Niacinamide at night for an extra boost of beauty rest. Niacinamide and hyaluronic acid, together, are a super skincare combination as they complement each other’s hydrating effects.

Niacinamides hydrating effects are down to the fact that it increases the levels of ceramides, fatty acids, and cholesterol in your stratum corneum. In contrast, hyaluronic acid regulates the water that comes in and out of your skin cells. Pairing niacinamide and hyaluronic acid together mean that you are tackling your skin’s hydration from both angles! In addition, Niacinamide helps boost collagen production while hyaluronic acid improves elasticity, so combining the two can help improve the appearance of fine lines and wrinkles.

Hyaluronic Acid

Hyaluronic acid, also known as hyaluronan, is a clear, gooey substance naturally produced by your body. The largest amounts of it are found in your skin, connective tissue, and eyes. Its main function is to retain water to keep your tissues lubricated and moist. Hyaluronic acid has a variety of uses. Many people take it as a supplement, but it’s also used in topical serums, eye drops, and injections. Hyaluronic acid is a naturally occurring substance that helps retain moisture in the skin and eyes and lubricates the joints. 

It also plays a crucial role in wound healing by controlling inflammation and redirecting blood flow to damaged tissue. Hyaluronic acid levels decrease as people age. This may contribute to the physical signs of aging, such as the appearance of wrinkles and age-related conditions, including osteoarthritis. Although hyaluronic acid is present in numerous cosmetic and medical products, its effects can vary from person to person.

Types Hyaluronic Acid

Hyaluronic acid is available in a variety of different forms.

1. Oral

Hyaluronic acid tablets have shown efficacy for treating several issues, including:

Skin hydration and wrinkle reduction

Joint pain

People should speak to their doctor or another healthcare professional before using any form of supplements, as they may interact with other medications.

2. Topical

Topical hyaluronic acid can come in the following forms:





Hyaluronic acid can help increase moisture levels in the skin and reduce signs of aging.

3. Injections

Because the body produces hyaluronic acid naturally, a person's chances of an allergic reaction are low. Therefore, hyaluronic acid in injection form can have a range of uses. It can have medical and cosmetic purposes. One cosmetic purpose for hyaluronic acid is fillers, including facial and lip fillers. A dermatologist injects hyaluronic acid into the lips to give them a plumper appearance.

Benefits of Hyaluronic Acid for the face and body

Promotes Healthier, More Supple Skin

Hyaluronic acid supplements can help your skin look and feel more superb. Roughly half of the hyaluronic acid in your body is present in your skin, which binds to water to help retain moisture. However, the natural aging process and exposure to things like ultraviolet radiation from the sun, tobacco smoke, and pollution can decrease its amounts in the skin. Taking hyaluronic acid supplements may prevent this decline by giving your body extra amounts to incorporate into the skin.

Doses of 120–240 mg per day for at least one month have significantly increased skin moisture and reduced dry skin in adults. Hydrated skin also reduces the appearance of wrinkles, which may explain why several studies show that supplementing with it can make skin appear smoother. Hyaluronic acid serums can reduce wrinkles, redness, and dermatitis when applied to the skin's surface. Some dermatologists even inject hyaluronic acid fillers to keep skin looking firm and youthful 

Can Speed Wound Healing

Hyaluronic acid also plays a crucial role in wound healing. It’s naturally present in the skin, but its concentrations increase when there is damage needed for repair. Hyaluronic acid helps wounds heal faster by regulating inflammation levels and signaling the body to build more blood vessels in the damaged area. Applying it to skin wounds has been shown to reduce the size of injuries and decrease pain faster than a placebo or no treatment at all.

Hyaluronic acid also has antibacterial properties, so it can help reduce the risk of infection when applied directly to open wounds. What’s more, it’s effective at combating gum disease, speeding up healing after tooth surgery, and eliminating ulcers when used topically in the mouth. While the research on hyaluronic acid serums and gels is promising, there has been no research to determine whether hyaluronic acid supplements can provide the same benefits. However, since oral supplements boost the levels of hyaluronic acid found in the skin, it’s reasonable to suspect they may give some help.

Relieve Joint Pain by Keeping Bones Well Lubricated

Hyaluronic acid is also found in the joints, where it keeps the space between your bones well lubricated. When the joints are lubricated, the bones are less likely to grind against each other and cause uncomfortable pain. Hyaluronic acid supplements are beneficial for people suffering from osteoarthritis, a degenerative joint disease caused by wear and tear on the joints over time.

Taking 80–200 mg daily for at least two months has been shown to significantly reduce knee pain in people with osteoarthritis, especially those between 40 and 70 years old. Hyaluronic acid can also be injected directly into the joints for pain relief. However, an analysis of over 12,000 adults found only a modest reduction in pain and a greater risk of adverse effects.

Soothe Acid Reflux Symptoms

New research shows hyaluronic acid supplements may help reduce symptoms of acid reflux. When acid reflux occurs, the stomach contents are regurgitated up into the throat, causing pain and damage to the esophagus lining. Hyaluronic acid may help soothe the damaged lining of the esophagus and speed up the recovery process. One test-tube study found that applying a mixture of hyaluronic acid and chondroitin sulfate to acid-damaged throat tissue helped it heal much faster than when no treatment was used.

Relieve Dry Eye and Discomfort

Approximately 1 out of 7 older adults suffer from dry eye symptoms due to reduced tear production or tears evaporating too quickly. Since hyaluronic acid is excellent at retaining moisture, it’s often used to treat dry eyes. Eye drops containing 0.2–0.4% hyaluronic acid have reduced dry eye symptoms and improved eye health. Contact lenses that contain slow-release hyaluronic acid are also being developed as a possible treatment for dry eye.

In addition, hyaluronic acid eye drops are frequently used during eye surgery to reduce inflammation and speed wound healing. While applying them directly to the eyes has been shown to decrease dry eye symptoms and improve overall eye health, it is unclear whether oral supplements have the same effects. No studies have examined the effects of hyaluronic acid supplements on dry eye, but it may be a future area of research.

Preserve Bone Strength

New animal research has begun to investigate the effects of hyaluronic acid supplements on bone health. Two studies have found that hyaluronic acid supplements can help slow the rate of bone loss in rats with osteopenia, the beginning stage of bone loss that precedes osteoporosis.

Test-tube studies have also shown that high doses of hyaluronic acid can increase the activity of osteoblasts, the cells responsible for building new bone tissue. While its effects on human bone health have not yet been studied, early animal and test-tube studies are promising.

Could Prevent Bladder Pain

Approximately 3–6% of women suffer from interstitial cystitis or painful bladder syndrome. This disorder causes abdominal pain and tenderness, along with a solid and frequent urge to urinate. While the causes of interstitial cystitis are unknown, hyaluronic acid has been found to help relieve the pain and urinary frequency associated with this condition when inserted directly into the bladder through a catheter.

It’s unclear why hyaluronic acid helps relieve these symptoms, but researchers hypothesize that it helps repair damage to bladder tissue, making it less sensitive to pain. Studies have not yet determined whether oral hyaluronic acid supplements can increase amounts in the bladder enough to have the same effects.

Side effects of Hyaluronic Acid

In general, hyaluronic acid supplements, topical products, and injections appear safe when people follow the instructions on how to use them. However, hyaluronic acid may produce adverse side effects and allergic reactions in some people. A person should always do a test patch before starting using a new skin product.

People who receive injections containing hyaluronic acid may experience the following side effects, which should clear up within a week:






These side effects are most likely to occur due to the injection process rather than the hyaluronic acid solution itself.


Niacinamide also called nicotinamide is a form of vitamin B-3, an essential nutrient. A B-3 deficiency can lead to disorders of the skin, kidneys, and brain. Taking Niacinamide can help prevent B-3 deficiency.

And there’s much more to this nutrient, especially when it comes to general skin health. Although more research is needed, topical Niacinamide may help treat certain skin conditions, including acne and eczema.

Benefits of Niacinamide

Overall, Niacinamide can help build proteins in the skin and lock in moisture to prevent environmental damage.

Individual benefits include:

Immunity: Niacinamide helps build keratin, a type of protein that keeps your skin firm and healthy.

Lipid Barrier: Niacinamide can help your skin grow a ceramide (lipid) barrier, which can, in turn, help retain moisture. This is beneficial for all skin types, especially if you have eczema or mature skin.

Minimizes Redness And Blotchiness: Niacinamide reduces inflammation, which may help ease redness from eczema, acne, and other inflammatory skin conditions.

Minimizes Pore Appearance: Keeping skin smooth and moisturized may have a secondary benefit — a natural reduction in pore size over time.

Regulates Oil: Moisture retention benefits aren’t just for those with dry skin types. Niacinamide can also help regulate the amount of oil the sebaceous glands produce and prevent your glands from going into overdrive.

Protects Against Sun Damage: Niacinamide can concurrently rebuild healthy skin cells while protecting them from damage caused by ultraviolet rays.

Treats Hyperpigmentation: Some research has found 5 percent niacinamide concentrations can help lighten dark spots. Benefits were seen after four weeks but not beyond two months. This benefit may be due to increased collagen production.

Minimizes Fine Lines And Wrinkles: Research has also found that the same concentration helped reduce some signs of sun damage that come with aging. This includes fine lines and wrinkles.

Protects Against Oxidative Stress: Niacinamide helps build cells in the skin while protecting them from environmental stresses, such as sunlight, pollution, and toxins.

Treats Acne: Niacinamide may be helpful for severe acne, especially inflammatory forms like papules and pustules. Over time, you may see fewer lesions and improved skin texture.

How to add Niacinamide to your Skin-Care routine?

Niacinamide is a perfect complement to just about any skincare routine; thanks to the wide variety of benefits it offers your skin. Not only is it helpful in boosting collagen production, but the gentle, anti-inflammatory nature of the ingredient can potentially decrease the risk of irritation from other active ingredients you may be using, including retinol and AHAs, such as glycolic acid.

Once you’ve decided on a skincare product containing Niacinamide, it’s worth performing a spot test to determine whether your skin agrees with this ingredient. Apply a small amount of the product to a small patch of skin and watch for any adverse reaction. “Generally, someone can determine whether they are sensitive to a product within the first few days of use. Do this with any new product, especially if you have sensitive skin and are more prone to an allergic response.

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